2022 Annual Meeting

Session: Advances in New Modalities: Peptides, Nucleic acids

Chair

Christopher Lowe, University of Massachusetts-Amherst

Co-Chairs

Satheesh Podaralla, Food and Drug Administration

Presentations

08:00 AM

(605a) Scaleup Considerations for Solid-Phase Peptide Synthesis in Highly Dynamic Packed Beds.
Harrison Rose, Mike Di Maso, Kyle E. Ruhl, Shane T. Grosser, François Lévesque, Kevin M. Maloney, U. Faruk Mansoor, Ritwika Ray, Danielle M. Schultz, Steven M. Silverman

08:24 AM

(605b) New Insights into the Difficulties and Importance of Dichloroacetic Acid Removal Post Detritylation in the Solid Phase Oligonucleotides Synthesis Cycle
Peng-Kai Kao, Todd Kajdan, Wei-Ming Sun, Timothy M. Braden, Chen-Chun Chen, Eric D. Moher, Martin Johnson, Yufei Wei, David Logsdon

08:48 AM

(605c) Process Bottleneck of Packed Bed Oligonucleotide Reactors Arising from Critical Flux Due to Solid Phase Compressibility
Yufei Wei, Martin Johnson, Wei-Ming Sun, Timothy M. Braden, Chen-Chun Chen, Al Khilevich

09:12 AM

(605d) Study of Factors Impacting Peptide Retention in Nanofiltration
Paridhi Agrawal, Kevin Seibert

09:36 AM

(605e) Digital Process Replica of RNA Manufacturing for Enabling Process Optimization, Technology Transfer and Techno-Economic Assessment
Simon Daniel, Zoltán Kis, Cleo Kontoravdi, Nilay Shah

10:00 AM

(605f) A 3D-Printed Microfluidic Device for High-Throughput Production of mRNA-Lipid Nanoparticles
Noah Malmstadt, Wan-Zhen Lin, Kristian Bostic