(213e) Integrating Biological Functions in Artificial Membranes

Some properties of artificial membranes, such as selectivity, control of fouling and self-cleaning, are still far from those of biological membranes. In biological systems, high selectivity is achieved by cascade separation mechanisms, and fouling is controlled by operating at low flux and by cleaning and regenerating the membrane in situ.

One of the strategies to improve the properties of artificial membranes is to engineer biohybrid materials by integrating biocomponents into synthetic nanostructured materials to mimic bio-structures, systems, functions.

The presentation will use case studies to show that in addition to the method by which a biocomponent (e.g., an enzyme, an antibody, a cell, etc.) is loaded onto a synthetic membrane and the physicochemical properties of the material, the topography and nanoarchitecture of the membrane play a critical role in preserving the structure of the biocomponent and its associated functions.

The need for nanostructured membranes specifically designed to accommodate and implement biological functions will be discussed.