(211h) CORE-SHELL AND ENCAPSULATED ADSORBENTS FOR FLOW THROUGH PURIFICATION OF LARGE BIOMOLECULES AND NANOPARTICLES

We examine the structural and functional properties of commercial agarose based core-shell resins and develop models to describe the kinetics of binding for proteins with a broad range of molecular mass in single and multiple component systems. We also describe the development and properties of novel adsorbents obtained by encapsulating ceramic hydroxyapatite particles in inert agarose beads for the adsorption of proteins and nucleic acids impurities.