Enhancement of bacterial peaks via Raman Spectroscopy has provided an efficient method of bacterial detection without lengthy cell cultures. We report the use of graphene nano-dots (GNDs) to chemically detect and enhance select bacterial peaks by a factor of ten. This demonstrates the charge transfer ability of electroactive bacteria and provides a platform for discussing chemical enhancement phenomena for biological sensing at the cellular level. By integrating the molecule energy levels of an analyte with cytoelectrons (4.66-4.74 eV) and a GND (~4.9 eV) substrate, we can design new cytobotic constructs leveraging cellular respiration beyond standard electrochemical devices.
