2021 Annual Meeting

Session: Reaction Engineering in Pharmaceuticals and Fine Chemicals

Chair

Gaurav Giri, University of Virginia

Co-Chair

Onkar Manjrekar, AbbVie Inc.

Presentations

08:00 AM

(446a) Continuous Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in a Packed Bed Flow Reactor Using an Easily Synthesized Siloxane Network-Supported Palladium Catalyst
Bradley Davis, Milad Abolhasani, Jeffrey Bennett

08:18 AM

(446b) Engineering Composite Hollow Fiber As a Heterogeneous Catalyst and Continuous-Flow Microfluidic Reactor for Sustainable Production of Fine Chemicals
Ali Rownaghi

08:36 AM

(446c) Development and Validation of Enzymatic Kinetic Model for the Synthesis of Cephalexin and Amoxicillin By Penicillin G Acylase at High Substrate and Product Concentrations
Patrick Harris, Ronald Rousseau, Martha Grover, Andy Bommarius

08:54 AM

(446e) Optimizing Multistep Continuous Flow Organic Synthesis with Bayesian Optimization and Robotics
Anirudh M.K. Nambiar, Christopher P. Breen, Travis Hart, Timothy Jamison, Klavs Jensen, Tim Kulesza

09:12 AM

(446f) A Process Monitoring Approach for Multistep Continuous Flow Pharmaceutical Manufacturing: Combining Dynamic Modeling and IR Spectroscopy with Changepoint Analysis
Thomas Roper, Cameron Armstrong, Yuma Miyai, Anna Formosa, Luke Rogers, Pratiik Kaushik

09:30 AM

(446g) Heat Transfer Characterization in Flow Reactors for Continuous Pharmaceutical Oxidations
Fatou Baka Diop, Gabriela Chong, Emily Gonzales, Andrew Teixeira

09:48 AM

(446h) Identification of Reaction Pathways Using in-Line Process Analytical Technology (PAT): UV-Vis Spectroscopic Approach
Farshid Mohammadparast, Ravi Teja Addanki Tirumala, Sundaram Bhardwaj Ramakrishnan, Marimuthu Andiappan