An increase in population and water scarcity in populated areas has increased the demand for more efficient ways to purify water. Diffusiophoresis is the migration of particles induced by a charge and concentration gradient. Colloids in waters migrate in response to the presence of the gradients. A rigorous reaction engineering analysis and computation fluid mechanics model were developed to demonstrate the ability of CO2 to form gradients and be recovered in a nearly closed loop separation system. Bench scale experiments were performed and demonstrate the ability to remove colloidal and particulate matter from lab grade water. A recycle design concept is proposed and validated for CO2 reuse and nearly closed loop operation.