2020 Virtual AIChE Annual Meeting

Session: Predictive Scale-Up/Scale-Down for Production of Pharmaceuticals and Biopharmaceuticals I

Chair

Jie Chen, Massachusetts Institute of Technology

Co-Chair

Niall Mitchell, Process Systems Enterprise

Presentations

08:00 AM

(435a) Reaction Kinetic Model Application to Speed up Development
Filipe Ataíde, Elisabete Mateus, Lucia Volta e Sousa, Marta Mourão, Ana Ribeiro, Fabrice Odille, Georges Assaf, Ugo Cocchini, Patrick Lo Brutto

08:15 AM

(435b) Utilizing Mechanistic Modelling to Support Scale-up of Fed-Batch Reaction Process
Marcello Bosco, Leonor Rosa, Niall Mitchell, Sam Wilkinson, Meera Mahadevan

08:30 AM

(435c) Scaling Down a Reactive Crystallization Using Various Mixing Models
Christopher Jordan, Yohanes Agustinus, Christopher Wilbert, Joseph Perona, Kira Ragazzo, Christopher Marton, Buck Holloway

08:45 AM

(435d) Centrifugation at Scale: Scaling up Based on Bench Top, Pilot Plant and Modeling Data
Laura McKee, Molly Riccitelli, Adelia Carragher, Xiao Serenity Hou, Elie Chaaya

09:00 AM

(435e) Experimental Confirmation of Scale-Down Mixing Models from Commercial to Lab Scale with CFD for Sterile Drug Products
Matthew Flamm, Tracey Mascaro, Amy L. Quach, Craig Ikeda, Brian Marks, Francis Kwofie, Kyra Schwartz

09:15 AM

(435f) Computational Approaches to Scale-up and Tech-Transfer in Agitated Filter Bed Drying
Kushal Sinha, Eric Murphy, Mothivel Mummudi Boopathy, Rahul Bharadwaj, Viraj Vilas Belekar, Shankar Subramaniam, Nandkishor Nere