2020 Virtual AIChE Annual Meeting

Session: Mixing Scale-Up and Scale-Down Issues in Pharmaceutical Processes

Chair

Luis Sierra, Merck Sharp & Dohme

Co-Chairs

Otute Akiti, Relypsa
Piero Armenante, New Jersey Institute of Technology

Presentations

08:00 AM

(426a) Towards an Understanding of Fluid and Particle History in a Turbulent Mixing Tank Using Large Eddy Simulation: Examining Effect of Different Impeller Types.
Matthew Flamm, Katherine Raudenbush

08:15 AM

(426b) Building the Predictive Process Engineering Toolbox to Define Mixing Parameters for Early-Stage Drug Product Manufacturing of Large Molecules
Robert Kuo, Zbynek Kalal, Julia Eckhoff, Smeet Deshmukh, Matthew Flamm, Sachin Mittal, Adam Procopio

08:30 AM

(426c) Hold Tank Mixing Profile Optimization for Potency Control in Filling a Shear Thinning Suspension Formulation
Richard Shields

08:45 AM

(426d) Efficient Process Development in the Micromixing-Mesomixing Space: The Bourne Protocol and Beyond
Aaron Sarafinas

09:00 AM

(426e) Development of a Mixing Index Provides a Means to Solve Many Industrial Mixing Problems
David Dickey

09:15 AM

(426f) Implementation of a Vapor-Liquid Equilibrium and Vapor Purge Model for Scale-up of a Transfer Hydrogenation
Federico Lora Gonzalez, Kira Ragazzo, Ronald Carrasquillo-Flores, Shawn Brueggemeier, Zhongping Shi

09:30 AM

(426g) Coupling Reaction Kinetics, Calorimetry and Mixing Studies for Successful Scale-up of Exothermic Reactions
João Sardinha, Filipe Ataíde, Ricardo Mendonça, Elsa Gonçalves, Ana Monteiro, Susana Nascimento