2020 Virtual AIChE Annual Meeting

Session: Mixing Scale-Up and Scale-Down Issues in Pharmaceutical Processes

Chair

Sierra, L., Merck Sharp & Dohme

Co-Chairs

Akiti, O., Relypsa
Armenante, P., New Jersey Institute of Technology

Presentations

08:00 AM

(426a) Towards an Understanding of Fluid and Particle History in a Turbulent Mixing Tank Using Large Eddy Simulation: Examining Effect of Different Impeller Types.
Flamm, M., Raudenbush, K.

08:15 AM

(426b) Building the Predictive Process Engineering Toolbox to Define Mixing Parameters for Early-Stage Drug Product Manufacturing of Large Molecules
Kuo, R., Kalal, Z., Eckhoff, J., Deshmukh, S., Flamm, M., Mittal, S., Procopio, A.

08:30 AM

(426c) Hold Tank Mixing Profile Optimization for Potency Control in Filling a Shear Thinning Suspension Formulation
Shields, R.

08:45 AM

(426d) Efficient Process Development in the Micromixing-Mesomixing Space: The Bourne Protocol and Beyond
Sarafinas, A.

09:00 AM

(426e) Development of a Mixing Index Provides a Means to Solve Many Industrial Mixing Problems
Dickey, D.

09:15 AM

(426f) Implementation of a Vapor-Liquid Equilibrium and Vapor Purge Model for Scale-up of a Transfer Hydrogenation
Lora Gonzalez, F., Ragazzo, K., Carrasquillo-Flores, R., Brueggemeier, S., Shi, Z.

09:30 AM

(426g) Coupling Reaction Kinetics, Calorimetry and Mixing Studies for Successful Scale-up of Exothermic Reactions
Sardinha, J., Ataíde, F., Mendonça, R., Gonçalves, E., Monteiro, A., Nascimento, S.