2019 AIChE Annual Meeting

Session: Protein Science and Engineering: High Throughput Screening and Characterization

Talks in this session are united by their development or use of high-throughput screening methods for protein engineering. Speakers will describe how their screens can be used for uncovering effects on protein function and interaction, enhancing non-standard amino acid incorporation, or discovering new therapeutic proteins and peptides.

Co-Chairs

Aditya Kunjapur, University of Delaware
Jason Boock, Miami University (OH)
Daniel Woldring, HHMI/Brandeis University

Presentations

03:30 PM

(608a) Novel High-Throughput Technology for Antibody Discovery Synthesizing the Virion Display and Yeast Display Platforms
Jamie Spangler

03:48 PM

(608b) Chemically Diverse Peptide Libraries Yield Potent Inhibitors of the p53-MDM2 Interaction
Tejas Navaratna, Greg Thurber

04:06 PM

(608c) Quantitative Analysis of Protein-Protein Interactions Using a Yeast-Yeast Two Hybrid Model
Kaitlyn Bacon, Abigail Blain, Matthew Burroughs, Nikki McArthur, Stefano Menegatti, Balaji Rao

04:24 PM

(608d) Strategies for Expanding Genetically Encoded Chemical Diversity in Yeast
Jessica T. Stieglitz, James Van Deventer

04:42 PM

(608e) Collateral Fitness Effects of Mutations
Jacob D. Mehlhoff, Frank W. Stearns, Marc Ostermeier, Dahlia Rohm, Buheng Wang, Erh-Yeh Tsou, Meng-Hsuan Hsiao, Nisita Dutta, Alan F. Rubin, Courtney E. Gonzalez

05:00 PM

(608f) Machine-Learning Guided Mutagenesis for Directed Evolution of Recombinant Proteins
Hikaru Nakazawa, Mitsuo Umetsu, Yutaka Saito, Misaki Oikawa, Tomoshi Kameda, Koji Tsuda

05:18 PM

(608g) High-Throughput Screens and Selections for Enzyme Function in Non-Model Bacteria
Joshua Michener