2019 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical

This poster session highlights academic and industrial research related to advancements in drug discovery, development, and manufacturing. Topics related to drug substance, drug product, and biopharmaceuticals are welcomed.

Chair

Shujauddin M. Changi, University of Michigan

Co-Chairs

Nil Tandogan, Eli Lilly & Co

Presentations

03:30 PM

(189q) Optimizing the Pharmaceutical Cleaning Process: Challenges and Opportunities
Rabah Mouras, Gavin Walker, Ahmad B. Albadarin
(189aa) Understanding Polymorphic Phase Transformations of Acetaminophen in Polymer-Based Formulation Processes
José Hernández Espinell, Betsy Orta, Vilmalí López-Mejías, Torsten Stelzer, Giovanni López Burgos
(189r) The Development of a 2-Step Buprenorphine Intermediate 5 Process
Wen-Chun Zhang
(189k) In-Line NIR Spectroscopy for Monitoring the Preparation of Ginkgo Biloba Extract Solid Dispersions By Hot-Melt Extrusion
Luming Liu, Haibin Qu
(189ac) Development of a Blistering Packaging Process with Nitrogen-Modified Headspace
Margaret R. Dowst, Jennifer M. Vandiver, Mark Oliveira, Niranjan S. Kodgule, Michael Young, Mark Tawa, Erica Connolly
(189g) Experimental Analysis of Influence Screw Configuration in View of Understanding Granulation Mechanism in Pharmaceutical Twin-Screw Melt Granulation
Shana Van de Steene, Thomas De Beer, Chris Vervaet, Jeroen Van Renterghem
(189o) Development of an Expanded Parametric PBE Using Experimental Data from a High Shear Wet Granulation Process
Madeline Candelaria, Luis F. Torrens-Sotomayor, Carlos Velazquez
(189ab) Application of Artificial Neural Network As a Predictive Tool for Continuous Liposome Processing
Sameera Sansare, Antonio Costa, Xiaoming Xu, Hossein Mohammadiarani, Celia Cruz, Su-Lin Lee, Diane Burgess, Bodhisattwa Chaudhuri
(189p) A Chemical Engineering Approach to Modelling Drug Dissolution and Transport Phenomena in the Lower Gastrointestinal Tract
Connor O'Farrell, Konstantinos Stamatopoulos, Mark Simmons, Hannah K. Batchelor, Eva M. Karlsson, Luca Marciani, Sarah Sulaiman
(189ae) Buckling of a Drying Colloidal Drop
Mahesh Tirumkudulu
(189d) Establishing Meaningful Alarm Limits for a Continuous Direct Compression Process
Jenna Brandon
(189b) Advancing from QbD to Operational Excellence in Continuous Pharmaceutical Manufacturing
G. V. Rex Reklaitis, Sudarshan Ganesh, Zoltan K. Nagy, Le Bao Dan Vo, Benjamin Rentz
(189i) Agitator Impact on the Net Weight Signal of a Loss-in-Weight Feeder Operating at Low Mass Flow Rates
Marcus O'Mahony, Steven Dale, Eric Dinarello, Greg Connelly, Ian Kinney, Hudson Gloria
(189l) Filtration Studies Combined with Mechanistic Modelling to Reliable API Process Understanding and Scale-up
Rui Pina Campos, Filipe Ataíde, Ana Cruz, Emília Leitão, Rui Loureiro
(189s) Arginine Interactions Resulting in Virus Inactivation
Christa Meingast, Pratik Umesh Joshi, Caryn Heldt
(189n) Forget Throughput, It’s about the Risk- Rethinking Dead-End Membrane Filtration Scale-up
Kelly Wei
(189u) Characterization of the Formulation-Process Interaction for Improved Thermal Bonding in the Manufacture of a Novel Ultra-Long Acting Oral Dosage Form
Sonia Holar, David Dufour, Susan Low, Tyler Grant, Kristie Sykes, Rose Kanasty, Juan Jaramillo Montezco
(189v) Development of pH -Responsive Disintegrating Matrices for Safe Intestinal Transit of Gastric Resident Dosage Forms
Juan Jaramillo Montezco, Sonia Holar, Kristie Sykes, Rose Kanasty, Tyler Grant, Marlene Schwarz, Susan Low, Jung Yang, Andrew Bellinger, David Alteruter
(189t) Once Weekly Oral Ivermectin for Prevention of Malaria Transmission in Zone IVb
Jung Yang, Rosemary Kanasty, Tyler Grant, Sonia Holar, Juan Jaramillo Montezco, Deblina Biswas, Adam Habshey, Susan Low
(189c) Application of Life-Cycle Concepts in Drug Substance Manufacturing
Ajay Babu Pazhayattil, Marzena Ingram
(189h) How a Material Property Library Can Promote Rapid Process Development
James Scicolone, Fernando J. Muzzio
(189j) Temperature Mapping of Pharmaceutical Trickle Bed Reactor for Continuous Hydrogenation
Huibo Sheng, David Pfisterer, Tomislav Ljubicic, Joel Hawkins, Jason Mustakis, Angel Diaz
(189a) A Comprehensive Sensitivity Analysis for Risk Assessment of a Pharmaceutical Crystallization Process
Merve Öner, Stuart Michael Stocks, Jens Abildskov, Gurkan Sin
(189w) Single-Use Centrifuge for Large Scale Separation and Collection of CHO and mAbs, and Other Cell Culture Applications
David Richardson
(189x) Solubility Enhancement of Hydrophobic Drug Molecules Via Amorphous Solid Dispersions and Flash Nanoprecipitation
Nicholas Caggiano, Robert K. Prud'homme, Rodney D. Priestley
(189z) Enhancing the Long-Term Storage Stability of Amorphous Drug-Polyelectrolyte Nanoparticle Complex Via Incorporation of Hypromellose
Kunn Hadinoto, Jia Wei Chew
(189e) Assessment of Blend Uniformity in a Continuous Tablet Manufacturing Process
Nobel O. Sierra-Vega, Rafael Méndez-Román
(189ad) Dropwise Additive Manufacturing for Pharmaceuticals
Andrew J. Radcliffe, Zoltan K. Nagy, G. V. Rex Reklaitis
(189f) Continuous Pharmaceutical Manufacturing of Uniform Crystals in Slug Flow
Mingyao Mou, Huayu Li, Bing-Shiou Yang, Mo Jiang
(189y) Comparison of Oral Drug Dissolution between Medium and Long Chain Unsaturated and Saturated Triglycerides: A Modeling-Based Approach
Bhavya Singh
(189m) Filtration Process Modeling and Scale-up for Robust Drug Substance Manufacturing
Wenbin Hu, Carlos Orihuela, Jace Fogle