2019 AIChE Annual Meeting

Session: Modeling and Design of Biopharmaceutical Processes

This session invites presentations related to the processing of large molecules encompassing both the drug substance and drug product. The topics would cover applications of mathematical modeling for process understanding and optimization. It would also cover topics on the experimentation-based process design. The presentations will showcase relevant examples and approaches that cover a wide range of unit operations used in biopharmaceutical processing.

Chair

Sinha, K., AbbVie Inc.

Co-Chair

Albrecht, J., Bristol-Myers Squibb

Presentations

08:00 AM

(471a) Development of a Segregated Cell Growth Model Structured By Dynamic Flux Balance Analysis
Kontoravdi, C., Diaz-Fernandez, P., Skeene, K., Finka, G., Barbosa, R.

08:21 AM

(471b) A Holistic Modelling Framework Describing CHO Cell Metabolism and Both Antibody and Host Cell Protein Glycosylation
Kotidis, P., del Val, I. J., Krambeck, F., Betenbaugh, M., Kontoravdi, C.

08:42 AM

(471c) Dynamic Simulation and Process Assessment of Cultivation Modes in Monoclonal Antibody Production Using Pilot-Scale Experimental Data
Badr, S., Sugiyama, H., Okamura, K.

09:24 AM

(471e) Mathematical Modeling of the Freezing of Pharmaceutical Solutions
Colucci, D., Fissore, D., Braatz, R. D.

09:45 AM

(471f) Combining Numerical Modelling (CFD), Statistical Modelling (MVDA) and Laboratory Experiments for the Optimization of Large Scale UF/DF Operations
O'Sullivan, J., Duffy, D.

10:06 AM

(471g) Engineering-Driven Application of Quality By Design to the Gmma Platform: Enabling the Production of Affordable and Effective Vaccines for Low and Middle Income Countries
Papathanasiou, M., Kis, Z., Sollai, L., Giannelli, C., Baccante, A., Colucci, A. M., Cappelletti, E., Pisoni, I., Palmieri, E., Ricchetti, B., Necchi, F., Koeberling, O., Martin, L. B., Shah, N., Campa, C., Micoli, F., Kontoravdi, C.