2019 AIChE Annual Meeting

Session: Mixing Scale-Up and Scale-Down Issues in Pharmaceutical and Biopharmaceutical Processes

Mixing issues and scale-up/scale-down strategies for the production of pharmaceutical and biopharmaceuticals.

Chair

Luis Sierra, Merck Sharp & Dohme

Co-Chairs

Piero Armenante, New Jersey Institute of Technology

Matthew Flamm, Merck & Co., Inc.

Presentations

08:00 AM

(470a) Defining a Scale-up Strategy for an Oil in Water Cosmetic Emulsion

Andrea Suaza Montalvo, Alvaro Orjuela

08:21 AM

(470b) Effective Scale-up of Aerated Fermentation Processes with Complex Rheology to Industrial Scale

Sören Bernauer, Christian Witz, Philipp Eibl, Johannes G. Khinast, Mathias Schöpf, Timo Hardiman

08:42 AM

(470c) Direct Numerical Simulation of Bioreactors Using GPUs

John A. Thomas

09:03 AM

(470d) Using Numerical Modelling (CFD) to Expedite Scale-up and Technology Transfer of Industrial Bioprocesses between Manufacturing Sites

Becca Dunne

09:24 AM

(470e) Use of Acoustic Emission for Identifying Gas-Liquid Mixing Regime in Agitated Vessels at Different Scales Applying Machine Learning

Giuseppe Forte, Federico Alberini, Mark Simmons, Hugh Stitt

09:45 AM

(470f) Hydrodynamics Investigation of USP Dissolution Testing Apparatus I (Basket Apparatus) and Effect of the Basket Mesh Size on Hydrodynamic Characteristics

Chadakarn Sirasitthichoke, Piero Armenante

10:06 AM

(470g) Efficiently Characterize Process Scalability in the Micromixing-Mesomixing Space Using the Bourne Protocol

Aaron Sarafinas