2019 AIChE Annual Meeting

Session: Enabling and Advancing Formulations in Drug Product

This session highlights research related to drug product processing for solubility enhancement or other advances in the manufacture of challenging oral formulations. Solubility enhancement includes, but is not limited to, processing of amorphous solid dispersions via spray drying or hot melt extrusion.

Chair

Brendon Ricart, Abbvie Inc.

Co-Chairs

Mehrdad Kheiripour, Neurocrine Biosciences Inc
Xue (Ida) Chen, The Dow Chemical Company

Presentations

08:00 AM

(640a) Possible Synergistic Effects of Binary Polymers in Enhancing Release of a Poorly Soluble Drug from Amorphous Solid Dispersions
Mahbubur Rahman, Alexander Coelho, Stephanie Ahmad, James Tarabokija, Sayali Bhujbal, Keanu Radgman, Ecevit Bilgili

08:18 AM

(640b) Modeling Fluidized Bed Impregnation of Active Pharmaceutical Ingredients Onto Porous Excipients
Benjamin Glasser, Fernando Muzzio, Plamen Grigorov

08:36 AM

(640c) The Interaction of Solvent and Hypromellose Acetate Succinate Relate to Pharmaceutical Spray Dried Dispersion
Daniel Burnett, Jin Zhao

08:54 AM

(640d) Effect of Preparative Methods on the Polymorph Found in Crystalline Solid-Dispersions of Flufenamic Acid
Karina Sanabria Ortiz, José Hernández Espinell, Vilmalí López-Mejías, Torsten Stelzer

09:12 AM

(640e) Methodology to Rapidly Screen Lyophilization Formulations
Christopher J. Morrison

09:30 AM

(640f) Towards Modelling the Morphology of Particles Obtained from Spray Dried Droplets
Hassan Abdullahi, Thomas Vetter, Christopher L. Burcham

09:48 AM

(640g) Prediction of the Solubility of Active Pharmaceutical Ingredients Using the SAFT-? Mie Group Contribution Approach
Malak Wehbe, Sara Febra, Spiros Kournopoulos, George Jackson, Claire S. Adjiman, Amparo Galindo

10:06 AM

(640h) Predicting the Stability of Biotherapeutics in Liquid and Solid Formulations
Sarah Hedberg, Daryl Williams