(6au) Reverse Perfluorocarbon Emulsions for Pulmonary Drug Delivery

Pulmonary drug delivery using water-in-perfluorocarbon reverse emulsions has the potential to improve traditional treatment methods of lung diseases. Liquid perfluorocarbons (PFC) function like air, providing a medium for gas exchange; and as a delivery vehicle, enabling deeper lung penetration of delivered drugs. Since most drugs are sparingly soluble in PFC liquids, aqueous drug solutions must be dispersed as a water/PFC emulsion. Several studies have confirmed drug-loaded PFC emulsions maintain therapeutic effects; however, few studies have engineered controlled release profiles that cater to specific therapeutic windows or disease states.

Teaching Interests:

Drug transport, Colloids and Surfaces, Physiology, Systems Modeling and Analysis for Biomedical Engineering