2018 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical

<p>This poster session highlight academic and industrial research related to advancements in drug discovery, development, and manufacturing. Topics related to drug substance, drug product, and biopharmaceuticals are welcomed.</p>

Chair

McMullen, J. P., Merck & Co. Inc.

Co-Chair

Marton, C. H., Celgene

Presentations

03:30 PM

(200w) Development and Scale-up of a Robust Impinging Jet Process Under GMP Conditions
Verma, A. A., Sinha, K., Shekhar, S.
(200ah) Effect of Solvent in Strip Film Manufacturing Containing BCS CLASS II Drugs VIA Solution Casting
Cetindag, E., Pentangelo, J., Dave, R.
(200ai) Droplet-Coalescence Kinetics for a Non-Newtonian Emulsion Using a Taylor-Couette Shear-Flow Reactor: Characterizing Phase-Separation Risk for a Pharmaceutical Ointment
Ketabchi-Haghighat, A., Vigil, R. D., Olsen, M., Sarkar, A.
(200k) Production of Anti-CD20 Monoclonal Antibody Biosimilar
Ou, J., Si, Y., Xu, N., Flanigan, D. D., Song, J., Zhou, L., Liu, X. M.
(200o) Liquid Phase Synthesis of Monodisperse PEGs By Nanostar Sieving
Cuccato, D., Gaffney, P., Schaepertoens, M., Livingston, A. G., Liu, R.
(200ae) Advancing Smart Manufacturing in Pharmaceutical Systems
Ganesh, S., Moreno, M., Su, Q., Rossi, F., Gonzalez, M., Nagy, Z. K., Reklaitis, G. V. R.
(200al) Anti-Static Agent Addition in Excipients – Always a Decent Way to Increase Powder Process-Ability in Pharmaceutical Industries?
Ribeyre, Q., Bocquet, S., Francqui, F., Lumay, G.
(200am) CRISPR-Cas9 Plasmid DNA Delivery to Endometrial Cancer Cells for Knockout of PLAC1
Givens, B. E., Devor, E. J., Salem, A. K.
(200l) Multi-Stage and Multi-Objective Design Tool for Process Design in Sterile Filling of Biopharmaceuticals
Shirahata, H., Zuercher, P., Badr, S., Sugiyama, H.
(200an) Sustained Release Polymeric Drug Delivery Systems to Inhibit ERK1/2 Activity
Givens, B. E., Naguib, Y. W., Tambunlertchai, S., Chitphet, K., Salem, A. K.
(200i) Continuous Protein Crystallization of Lysozyme
Chen, W., Yang, H., Li, X., Peczulis, P., Inguva, P., Heng, J. Y. Y.
(200ao) Functionalized Ultra-Thin Shell Microcapsule for Targeted Encapsulation and Release
Zhang, L., Didier, J., Weitz, D. A.
(200aa) Nucleation Kinetics of Pharmaceutical Co-Crystals
McTague, H.
(200e) Rapid and Efficient Development of Downstream Bio-Pharmaceutical Processing Alternatives
Colombo, G., Udugama, I. A., Gernaey, K. V., Mansouri, S. S.
(200j) Development of a Cation Exchange Chromatography Step for Robust Impurity Clearance and Improved Polysorbate 80 Stability in the Drug Product of a Monoclonal Antibody
Miller, J., Chmielowski, R. A., Li, H., Clark, S.
(200ac) One Step Purification of Curcumin from Its Lower Grades Via Particle Mediated Crystallization
Kannuchamy, V. K., Ramisetty, K., Gamidi, R. K., Heffernan, C., Krishnaraj, R. D., Hodnett, B. K., Rasmuson, A.
(200b) Evaluation of Microfluidic Device Designs for a Potassium Release Toxicity Assay
Wakim, J., Orbey, N., Barry, C.
(200a) Multi-Scale Modeling in Immuno-Oncology to Support Immunotherapy Drug Development
Ghasemi, M., Mager, D. E.
(200ad) Ternary Phase Diagram and Population Balace Model for Solvent-Mediated Phase Transformation of Lansoprazole
Zong, S., Wu, H., Hao, H., Wang, J., Liu, Q.
(200s) Stoichiometry Identification in Pharmaceutical Reactions Using Dynamic Response Surface Methodology and Target Factor Analysis
Dong, Y., Georgakis, C., Santos-Marques, J., Mustakis, J., Wang, K., McMullen, J. P., Grosser, S. T.
(200y) Manipulation of Crystal Morphology of Zoxamide Based on Phase Diagram and Crystal Structure Analysis
Wu, H., Zong, S., Liu, Q., Wang, J., Hao, H.
(200g) Continuous Processing of Doxorubicin-Loaded Liposomes
Costa, A., Mukherjee, R., Gupta, A., Yenduri, G., Xu, X., Chaudhuri, B., Burgess, D., Cruz, C.
(200t) Heat Transfer Transients in Semi-Batch Systems: A Computational Approach to Process Intensification and Mitigating Process Hazards
Jain, D., Kant, J., Dalvi, V., Mathpati, C.
(200p) Virtual Screening of Process Parameters for Pharmaceutical Drying Operation: A Combined DoE-CFD Approach
Jain, D., Kant, J., Dalvi, V., Mathpati, C.
(200d) Peptoid JPT1A Reduces RAGE Expression and Attenuates Inflammatory Response: A Potential AD Therapeutic
Wolf, L. M., Servoss, S., Moss, M. A.
(200f) Pump-Down the Mycobacterium Tuberculosis: A DNA Gyrase/P-Glycoprotein Combined Inhibition Approach
Laurini, E., Aulic, S., Fermeglia, M., Carta, A., Marson, D., Briguglio, I., Ibba, R., Pricl, S.
(200h) Experiments and Multi-Scale Models to Understand Liposome Processing Using a Turbulent Jet in Co-Flow
Mukherjee, R., Costa, A., Gupta, A., Yenduri, G., Xu, X., Cruz, C., Chaudhuri, B., Burgess, D.
(200x) Single-Step Continuous Purification from Liquid-Liquid-Solid Mixture: Design and Experimental Implementation for an HIV Drug Intermediate
Jiang, M., Lu, A. E., Gupton, F., Braatz, R., Li, B., Roper, T.
(200ag) Effect of Process Parameters on Stability of Lactate Dehydrogenase during Bulk Freeze-Thaw
Minatovicz, B., Chaudhuri, B., Bogner, R., Sun, L., Fan, T. H., Li, J. Q.
(200n) Increasing Capacity and Lifetime of Reverse Phase Resin
McKechnie, W., Tugcu, N., Kandula, S.
(200aj) Unique Polymorph and Amorphous Dispersion Formation of Suberic Acid Using Monodisperse Droplet Evaporation
Snyder, R. C., Karakis, V., Ditmar, E., Vostal, K. R.
(200ab) Extrudability Analysis of Drug Loaded Pastes for 3D Printing of Modified Release Tablets
Alayoubi, A., Zidan, A., Coburn, J., Ghammraoui, B., Cruz, C., Ashraf, M.
(200m) Comparison of Batch and Continuous Biopharmaceutical Antibody Production Based on Techno-Economic Analysis
Yang, O., Ierapetritou, M.
(200c) Effects of Unsaturated Phospholipid Dilinoleoylphosphatidylcholine on Degradation of Phospholipid Vesicles Catalyzed By a Model Phospholipase A2
Zhang, P., Villanueva, V., Kalkowski, J., Liu, C., Bu, W., Lin, B., Liu, Y., Pham, T. H.
(200ak) Importance of the Reaction Kinetics of Drug-Bile Micelle Formation in Oral-Drug Absorption Modeling
Shoemaker, B., Ibrahim, F., Shanker, R. M., Sarkar, A.
(200u) Plasmonic Nanocatalysts for Continuous Synthesis of Drug Substances: An Example of Visible-Light Mediated Cross Coupling Reactions
Teja, R., Mohammadparast, F., Dadgar, A., Andiappan, M.
(200af) Dropwise Manufacturing of Oral Solid Dosage Forms Using Powder Slurries
Radcliffe, A. J., Nagy, Z. K., Reklaitis, G. V.
(200z) Crystallization Kinetic Measurement and Parameter Estimation Utilizing Population Balance Model in a Dynamic/Oscillatory Baffle Crystallizer
Liu, C. Y., Barton, A., Firth, P., Wood, D., Speed, J., Eren, A., Nagy, Z. K.