2018 AIChE Annual Meeting

Session: Poster Session: Pharmaceutical

<p>This poster session highlight academic and industrial research related to advancements in drug discovery, development, and manufacturing. Topics related to drug substance, drug product, and biopharmaceuticals are welcomed.</p>

Chair

Jonathan P. McMullen, Merck & Co. Inc.

Co-Chair

Presentations

03:30 PM

(200c) Effects of Unsaturated Phospholipid Dilinoleoylphosphatidylcholine on Degradation of Phospholipid Vesicles Catalyzed By a Model Phospholipase A2
Pin Zhang, Veronica Villanueva, Joseph Kalkowski, Chang Liu, Wei Bu, Binhua Lin, Ying Liu, Tiep Hoang Pham
(200ac) One Step Purification of Curcumin from Its Lower Grades Via Particle Mediated Crystallization
Vasanth Kumar Kannuchamy, Kirankumar Ramisetty, Rama Krishna Gamidi, Claire Heffernan, Renuka Devi Krishnaraj, B. Kieran Hodnett, Ake Rasmuson
(200b) Evaluation of Microfluidic Device Designs for a Potassium Release Toxicity Assay
Joseph Wakim, Nese Orbey, Carol Barry
(200a) Multi-Scale Modeling in Immuno-Oncology to Support Immunotherapy Drug Development
Mohammad Ghasemi, Donald E. Mager
(200s) Stoichiometry Identification in Pharmaceutical Reactions Using Dynamic Response Surface Methodology and Target Factor Analysis
Yachao Dong, Christos Georgakis, Jacob Santos-Marques, Jason Mustakis, Ke Wang, Jonathan P. McMullen, Shane T. Grosser
(200g) Continuous Processing of Doxorubicin-Loaded Liposomes
Antonio Costa, Raj Mukherjee, Anand Gupta, Gowtham Yenduri, Xiaoming Xu, Bodhisattwa Chaudhuri, Diane Burgess, Celia Cruz
(200d) Peptoid JPT1A Reduces RAGE Expression and Attenuates Inflammatory Response: A Potential AD Therapeutic
Lauren M. Wolf, Shannon Servoss, Melissa A. Moss
(200h) Experiments and Multi-Scale Models to Understand Liposome Processing Using a Turbulent Jet in Co-Flow
Raj Mukherjee, Antonio Costa, Anand Gupta, Gowtham Yenduri, Xiaoming Xu, Celia Cruz, Bodhisattwa Chaudhuri, Diane Burgess
(200ag) Effect of Process Parameters on Stability of Lactate Dehydrogenase during Bulk Freeze-Thaw
Bruna Minatovicz, Bodhisattwa Chaudhuri, Robin Bogner, Li Sun, Tai-Hsi Fan, Ji-Qin Li
(200aj) Unique Polymorph and Amorphous Dispersion Formation of Suberic Acid Using Monodisperse Droplet Evaporation
Ryan C. Snyder, Victoria Karakis, Erin Ditmar, Kurt R. Vostal
(200j) Development of a Cation Exchange Chromatography Step for Robust Impurity Clearance and Improved Polysorbate 80 Stability in the Drug Product of a Monoclonal Antibody
Justin Miller, Rebecca A. Chmielowski, Hong Li, Seth Clark
(200af) Dropwise Manufacturing of Oral Solid Dosage Forms Using Powder Slurries
Andrew J. Radcliffe, Zoltan K. Nagy, Gintaras V. Reklaitis
(200w) Development and Scale-up of a Robust Impinging Jet Process Under GMP Conditions
Anuj A. Verma, Kushal Sinha, Shashank Shekhar
(200ah) Effect of Solvent in Strip Film Manufacturing Containing BCS CLASS II Drugs VIA Solution Casting
Eylul Cetindag, John Pentangelo, Rajesh Dave
(200o) Liquid Phase Synthesis of Monodisperse PEGs By Nanostar Sieving
Danilo Cuccato, Piers Gaffney, Marc Schaepertoens, Andrew G. Livingston, Ruiyi Liu
(200al) Anti-Static Agent Addition in Excipients – Always a Decent Way to Increase Powder Process-Ability in Pharmaceutical Industries?
Quentin Ribeyre, Simon Bocquet, Filip Francqui, Geoffroy Lumay
(200am) CRISPR-Cas9 Plasmid DNA Delivery to Endometrial Cancer Cells for Knockout of PLAC1
Brittany E. Givens, Eric J. Devor, Aliasger K. Salem
(200an) Sustained Release Polymeric Drug Delivery Systems to Inhibit ERK1/2 Activity
Brittany E. Givens, Youssef W. Naguib, Supreeda Tambunlertchai, Khanidtha Chitphet, Aliasger K. Salem
(200ao) Functionalized Ultra-Thin Shell Microcapsule for Targeted Encapsulation and Release
Liyuan Zhang, Johnathan Didier, David A. Weitz
(200u) Plasmonic Nanocatalysts for Continuous Synthesis of Drug Substances: An Example of Visible-Light Mediated Cross Coupling Reactions
Ravi Teja, Farshid Mohammadparast, Andishaeh Dadgar, Marimuthu Andiappan
(200y) Manipulation of Crystal Morphology of Zoxamide Based on Phase Diagram and Crystal Structure Analysis
Hao Wu, Shuyi Zong, Qi Liu, Jingkang Wang, Hongxun Hao
(200t) Heat Transfer Transients in Semi-Batch Systems: A Computational Approach to Process Intensification and Mitigating Process Hazards
Deepak Jain, Joydeep Kant, Vishwanath Dalvi, Channamallikarjun Mathpati
(200p) Virtual Screening of Process Parameters for Pharmaceutical Drying Operation: A Combined DoE-CFD Approach
Deepak Jain, Joydeep Kant, Vishwanath Dalvi, Channamallikarjun Mathpati
(200f) Pump-Down the Mycobacterium Tuberculosis: A DNA Gyrase/P-Glycoprotein Combined Inhibition Approach
Erik Laurini, Suzana Aulic, Maurizio Fermeglia, Antonio Carta, Domenico Marson, Irene Briguglio, Roberta Ibba, Sabrina Pricl
(200x) Single-Step Continuous Purification from Liquid-Liquid-Solid Mixture: Design and Experimental Implementation for an HIV Drug Intermediate
Mo Jiang, Amos E. Lu, Frank Gupton, Richard Braatz, Boxuan Li, Thomas Roper
(200n) Increasing Capacity and Lifetime of Reverse Phase Resin
William McKechnie, Nihal Tugcu, Sunitha Kandula
(200ab) Extrudability Analysis of Drug Loaded Pastes for 3D Printing of Modified Release Tablets
Alaadin Alayoubi, Ahmed Zidan, James Coburn, Bahaa Ghammraoui, Celia Cruz, Muhammad Ashraf
(200m) Comparison of Batch and Continuous Biopharmaceutical Antibody Production Based on Techno-Economic Analysis
Ou Yang, Marianthi Ierapetritou
(200ak) Importance of the Reaction Kinetics of Drug-Bile Micelle Formation in Oral-Drug Absorption Modeling
Brian Shoemaker, Fady Ibrahim, Ravi M. Shanker, Avik Sarkar
(200ad) Ternary Phase Diagram and Population Balace Model for Solvent-Mediated Phase Transformation of Lansoprazole
Shuyi Zong, Hao Wu, Hongxun Hao, Jingkang Wang, Qi Liu
(200z) Crystallization Kinetic Measurement and Parameter Estimation Utilizing Population Balance Model in a Dynamic/Oscillatory Baffle Crystallizer
Claire Yiqing Liu, Alastair Barton, Paul Firth, Dan Wood, Jonathon Speed, Ayse Eren, Zoltan K. Nagy
(200ai) Droplet-Coalescence Kinetics for a Non-Newtonian Emulsion Using a Taylor-Couette Shear-Flow Reactor: Characterizing Phase-Separation Risk for a Pharmaceutical Ointment
Arya Ketabchi-Haghighat, R. Dennis Vigil, Michael Olsen, Avik Sarkar
(200k) Production of Anti-CD20 Monoclonal Antibody Biosimilar
Jianfa Ou, Yingnan Si, Ningning Xu, Daniel D. Flanigan, Jiajia Song, Lufang Zhou, X. Margaret Liu
(200ae) Advancing Smart Manufacturing in Pharmaceutical Systems
Sudarshan Ganesh, Mariana Moreno, Qinglin Su, Francesco Rossi, Marcial Gonzalez, Zoltan K. Nagy, G. V. Rex Reklaitis
(200l) Multi-Stage and Multi-Objective Design Tool for Process Design in Sterile Filling of Biopharmaceuticals
Haruku Shirahata, Philipp Zuercher, Sara Badr, Hirokazu Sugiyama
(200i) Continuous Protein Crystallization of Lysozyme
Wenqian Chen, Huaiyu Yang, Xiaoyu Li, Peter Peczulis, Pavan Inguva, Jerry Y.Y. Heng
(200aa) Nucleation Kinetics of Pharmaceutical Co-Crystals
Hannah McTague
(200e) Rapid and Efficient Development of Downstream Bio-Pharmaceutical Processing Alternatives
Giorgio Colombo, Isuru A. Udugama, Krist V. Gernaey, Seyed Soheil Mansouri