2018 AIChE Annual Meeting

Session: Multivariate Experimentation and Modeling for Pharmaceutical Products and Processes

This session illustrates the advantages of integrating multivariate experimentation and modeling concepts into product and process development to support pharmaceutical manufacturing. Drug substance and drug product applications from industry and academia are both considered for this session track. Contributions that incorporate multivariate process modeling with experimental designs to optimize product and process performance in drug substance and/or drug product manufacturing are encouraged for submission.

Chair

Yuesheng Ye, Food and Drug Administration

Co-Chair

Nil Tandogan, Eli Lilly & Co

Presentations

08:00 AM

(470a) Accelerating High-Throughput Experimentation with Templated Statistical Analysis
Jacob Albrecht, Victor W. Rosso, Eric M. Saurer, Grace Chiou, Frederick Roberts, Jacob Janey, Jose Tabora, Brendan C. Mack

08:21 AM

(470b) Process Fingerprinting Tools in the Development of an Alkylation Reaction
Kevin Stone, Brian Wyvratt, Emmanuel Adachi, Jonathan P. McMullen, Marguerite Mohan

08:42 AM

(470c) Reactor Design for Continuous Synthesis of Pharmaceutical Intermediates: Correlation of Computational Fluid Dynamics and Design of Experiment Approaches
Thomas Roper, Michael Bortner, Cameron Armstrong, Cailean Pritchard, Mariam Ibrahim, Daniel Cook, Bimbisar Desai, Yizheng Chen, Brian Marquardt, Patrick Whitham, Thouakesseh Zoueu

09:03 AM

(470d) Optimal Design of Experiments for Building Fundamental Models of Pharmaceutical Production Processes
Ali Shahmohammadi, Kimberley B. McAuley

09:24 AM

(470e) Model-Based Design of Experiments for Pharmaceutical Reaction Development
Kevin Stone, Jonathan P. McMullen, Dan Willard

09:45 AM

(470f) Defining the Optimal Operating Window for Pharmaceutical Reactions Using the Dynamic Response Surface Methodology for All Measured Species
Yachao Dong, Christos Georgakis, Jason Mustakis, Joel Hawkins, Jonathan P. McMullen, Shane T. Grosser

10:06 AM

(470g) Sensitivity Analysis and Identification of Feasible Region of a Wet Granulation Continuous Pharmaceutical Manufacturing Process
Marianthi Ierapetritou, Rohit Ramachandran, Nirupaplava Metta