2018 AIChE Annual Meeting

Session: Enabling and Advanced Formulations in Drug Product Processing II: Focus on Stability

These sessions highlight research related to drug product processing for solubility enhancement or other advances in the manufacture of challenging oral formulations. Solubility enhancement includes, but is not limited to, processing of amorphous solid dispersions via spray drying or hot melt extrusion. This session focuses on physical and chemical stability in advanced or enabled formulations.

Chair

Kucuk, G., Boehringer Ingelheim

Co-Chair

Peragine, J., Bristol-Myers Squibb Co

Presentations

03:30 PM

(402a) In Situ Studies of Phase Separation in Amorphous Solid Dispersions (ASDs) Using the QCM-D
Isbell, M. A., Heng, J., Zhang, G. G. Z.

03:51 PM

(402b) Mathematical Models for the Stability of Atropisomer-Forming Drug Substance in a Spray-Dried Dispersion Formulation
Tabora, J., Razler, T. M., He, B.

04:12 PM

(402c) Study of Nimesulide Recrystallization Kinetics By Particle Sizing, Microscopy, and Raman
Alcacio, T. E., Hsiao, G.

04:33 PM

(402d) Revealing Polymorphic Phase Transformations in Polymer-Based Hot Melt Extrusion Processes
Stelzer, T., Lopez-Mejias, V., Hernandez Espinell, J.

04:54 PM

(402e) Development of a Tablet Manufacturing Line Via Hot-Melt Extrusion and Strand Pelletization
Hörmann, T. R., Scheibelhofer, O., Rehrl, J., Funke, A., Paudel, A., Khinast, J. G.

05:15 PM

(402f) Exploring Mesoporous Supports As a Means to Separate Physical Property Control from Crystallization
Polster, C. S., Burt, J., Merritt, J., Polizzi, M., Greenwood, D. E., Aburub, A.

05:36 PM

(402g) Generation of Stable Nanobubbles Following Reconstitution of Lyophilized Protein Formulations: Effects of Excipient Structure on Nanobubble Formation
Snell, J., Randolph, T.