2018 AIChE Annual Meeting

Session: Enabling and Advanced Formulations in Drug Product Processing I: Focus on Dissolution

These sessions highlight research related to drug product processing for solubility enhancement or other advances in the manufacture of challenging oral formulations. Solubility enhancement includes, but is not limited to, processing of amorphous solid dispersions via spray drying or hot melt extrusion. This session focuses on drug release from advanced or enabled formulations.

Chair

Brendon Ricart, Abbvie Inc.

Co-Chair

Kristin J. Ploeger, Massachusetts Institute of Technology

Presentations

12:30 PM

(336a) Griseofulvin-Laden Extrudates Prepared Via Nanoextrusion: Impact of Dry-Milling on Dissolution Enhancement
Ecevit Bilgili, Meng Li, Casey Furey, Jeffery Skros, Rajesh Dave

12:51 PM

(336b) ­­­­the Effect of Inorganic Salt on Disintegration of Tablets with High Loadings of Kollidon® VA64-Based Amorphous Solid Dispersion
Hanmi Xi, Jie Ren, Julie Novak, Eric Kemp, Greg Johnson, Jerry R. Klinzing, Mary Ann Johnson, Wei Xu

01:12 PM

(336c) Miniaturized Formulation and Processability Screening for the Rational Design of Ethylene Vinyl Acetate Based Co-Extrudates
Ioannis Koutsamanis, Simone Eder, Stefan Mohr, Karin Eggenreich, Michela Beretta, Amrit Paudel, Klaus Nickisch, Maika Friedrich, Eva Roblegg

01:33 PM

(336d) Advances in Dissolution Modeling for Oral Dosage Forms with Amorphous Solid Dispersions
Mafalda Paiva, Pedro Valente, Ricardo Sousa, João Henriques, Márcio Temtem

01:54 PM

(336e) Modeling the Bead-Dissolution Kinetics for Composite Melt-Spray Congealed (MSC) Multiparticulates
Avik Sarkar, Brian Shoemaker

02:15 PM

(336f) Linking Process, Product and Performance By Raman Imaging Analysis
Pedro Valente, Mafalda Paiva, Patrícia Nunes, Márcio Temtem, Constança Cacela, Ana Aguiar-Ricardo, Susana Campos

02:36 PM

(336g) Repurposing Pollen Grains for Oral Delivery of Biologics
Pedro Gonzalez-Cruz, Shantanu V. Lale, Md Jasim Uddin, Shashwati Atwe, Noureddine Abidi, Harvinder Singh Gill