2018 AIChE Annual Meeting

Session: Enabling and Advanced Formulations in Drug Product Processing I: Focus on Dissolution

These sessions highlight research related to drug product processing for solubility enhancement or other advances in the manufacture of challenging oral formulations. Solubility enhancement includes, but is not limited to, processing of amorphous solid dispersions via spray drying or hot melt extrusion. This session focuses on drug release from advanced or enabled formulations.

Chair

Ricart, B., Abbvie Inc.

Co-Chair

Ploeger, K. J., Massachusetts Institute of Technology

Presentations

12:30 PM

(336a) Griseofulvin-Laden Extrudates Prepared Via Nanoextrusion: Impact of Dry-Milling on Dissolution Enhancement
Bilgili, E., Li, M., Furey, C., Skros, J., Dave, R.

12:51 PM

(336b) ­­­­the Effect of Inorganic Salt on Disintegration of Tablets with High Loadings of Kollidon® VA64-Based Amorphous Solid Dispersion
Xi, H., Ren, J., Novak, J., Kemp, E., Johnson, G., Klinzing, J. R., Johnson, M. A., Xu, W.

01:12 PM

(336c) Miniaturized Formulation and Processability Screening for the Rational Design of Ethylene Vinyl Acetate Based Co-Extrudates
Koutsamanis, I., Eder, S., Mohr, S., Eggenreich, K., Beretta, M., Paudel, A., Nickisch, K., Friedrich, M., Roblegg, E.

01:33 PM

(336d) Advances in Dissolution Modeling for Oral Dosage Forms with Amorphous Solid Dispersions
Paiva, M., Valente, P., Sousa, R., Henriques, J., Temtem, M.

01:54 PM

(336e) Modeling the Bead-Dissolution Kinetics for Composite Melt-Spray Congealed (MSC) Multiparticulates
Sarkar, A., Shoemaker, B.

02:15 PM

(336f) Linking Process, Product and Performance By Raman Imaging Analysis
Valente, P., Paiva, M., Nunes, P., Temtem, M., Cacela, C., Aguiar-Ricardo, A., Campos, S.

02:36 PM

(336g) Repurposing Pollen Grains for Oral Delivery of Biologics
Gonzalez-Cruz, P., Lale, S. V., Uddin, M. J., Atwe, S., Abidi, N., Gill, H. S.