2017 Annual Meeting

Session: Protein Structure, Function, and Stability II: Aggregation & Disease

We invite submissions pertaining to protein structure, function, stability, and dynamics. Studies that utilize experimental and/or computational approaches are welcome. Topics include, but are not limited to, structural or functional analysis, engineering of new proteins by structure-based design, effects of post-translational modifications, and analysis of protein conformational stability.

Chair

Luo, R., GSK

Co-Chairs

Yoon, S., University of Massachusetts Lowell
Li, H., University of California, Irvine

Presentations

12:30 PM

(570a) Engineering a Self-Assembling Peptide System Derived from Beta-Amyloid
Candreva, J., Chau, E., Kim, J. R.

12:48 PM

(570b) Competition between Ligands: How Retinol-Binding Protein and Beta-Amyloid Compete for Binding to Transthyretin
Mangrolia, P., Est, C., Murphy, R. M.

01:06 PM

(570c) Understanding the Role of Glycine in Amyloid Protein Aggregation through Rationally Designed Protein Sequences
Vance, S. Z., Moss, M. A., Crawford, J., Hall, R., Booth, G. L., Hestekin, C. N.

01:24 PM

(570d) N-Terminal Hypothesis for Alzheimer’s Disease: Analyzing Dimers of a ? peptide and its Protective and Causative Mutants
Sharma, B., Ranganathan, S. V., Sorci, M., Lennon, C., Van Deventer, J., Scimemi, A., Belfort, G.

01:42 PM

(570e) Computational Modeling of Amyloid Aggregation Kinetics to Gain Insights into the Effect of Ions on Amyloid Aggregation
Sharma, A., Behrens, S. H., Chernoff, Y. O., Bommarius, A., Rose, H. B.

02:00 PM

(570f) Human Islet Amyloid Polypeptide: Identifying Early-Stage Aggregation Mechanisms through Molecular Simulation
Guo, A., de Pablo, J. J.

02:18 PM

(570g) The Role of Cholesterol in Membrane Protein Activity
Robinson, A. S.