2017 Annual Meeting

Session: Protein Structure, Function, and Stability II: Aggregation & Disease

We invite submissions pertaining to protein structure, function, stability, and dynamics. Studies that utilize experimental and/or computational approaches are welcome. Topics include, but are not limited to, structural or functional analysis, engineering of new proteins by structure-based design, effects of post-translational modifications, and analysis of protein conformational stability.

Chair

Co-Chairs

Seongkyu Yoon, University of Massachusetts Lowell
Han Li, University of California, Irvine

Presentations

12:30 PM

(570a) Engineering a Self-Assembling Peptide System Derived from Beta-Amyloid
Jason Candreva, Edward Chau, Jin Ryoun Kim

12:48 PM

(570b) Competition between Ligands: How Retinol-Binding Protein and Beta-Amyloid Compete for Binding to Transthyretin
Parth Mangrolia, Chandler Est, Regina M. Murphy

01:06 PM

(570c) Understanding the Role of Glycine in Amyloid Protein Aggregation through Rationally Designed Protein Sequences
S. Zeb Vance, Melissa A. Moss, Jamie Crawford, Rachel Hall, Gram L. Booth, Christa N. Hestekin

01:24 PM

(570d) N-Terminal Hypothesis for Alzheimer’s Disease: Analyzing Dimers of a ? peptide and its Protective and Causative Mutants
Bhanushee Sharma, Srivathsan V. Ranganathan, Mirco Sorci, Christopher Lennon, James Van Deventer, Annalisa Scimemi, Georges Belfort

01:42 PM

(570e) Computational Modeling of Amyloid Aggregation Kinetics to Gain Insights into the Effect of Ions on Amyloid Aggregation
Aditi Sharma, Sven H. Behrens, Yury O. Chernoff, Andy Bommarius, Harrison B. Rose

02:00 PM

(570f) Human Islet Amyloid Polypeptide: Identifying Early-Stage Aggregation Mechanisms through Molecular Simulation
Ashley Guo, Juan J. de Pablo

02:18 PM

(570g) The Role of Cholesterol in Membrane Protein Activity
Anne S. Robinson