2015 AIChE Annual Meeting Proceedings
(759f) Application of Multivariate Latent Variable Methods to Drug Product Development
This work presents three case studies of the use of Multivariate Latent Variable Methods (LVM) in pharmaceutical development: i) a root-cause investigation into the compression behavior of powder blend for oral dosage form manufacture, and further implications for commercial scale-up; ii) the study of the feasibility to transfer a roller compaction process from one roller compaction unit to another of a different brand and design; and iii) the use of LVM to develop a solvent replacement system based on solvatochromic properties of solvents and the further coupling with optimization technology for a D-Optimal selection of solvents for experimental screening.