(601d) An Inflammation Responsive Nano-Fiber Platform for Controlled Drug Delivery

We have developed an autonomous Nano-Fiber delivery system that titrates the amount of drug released in response to the level of inflammation, ensuring the drug is released only when needed at a therapeutically relevant concentration. Translation of such technology would represent a paradigm shift in the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease which has characteristic flares followed by periods of lower disease activity. We have evaluated its ability to release drugs in response to enzymes that are abundant in human synovial fluid, ulcerated gut tissue, and in limb transplants using a series of in vitro and in vivo experiments.