2014 AIChE Annual Meeting

Session: Protein Engineering III: Therapeutics

This session will focus on protein engineering for therapeutic applications, with an emphasis on emerging topics and recent successes. Potential areas of interest include, but are not limited to, engineered antibodies for cell targeting and imaging, antibodies involved in disease pathologies, and advances in antibody therapeutics.

Chair

Xin Ge, University of California, Riverside

Co-Chairs

Laura Segatori, Rice University
Danielle Tullman-Ercek, University of California
Tamara L. Kinzer-Ursem, Purdue University

Presentations

08:30 AM

(467a) Synergy and Stability in the Treatment of Pertussis: Bispecific Antibody Vs Binary Mixture?
Ellen K Wagner, Jennifer A Maynard

08:48 AM

(467b) Optimized or-Gate Chimeric Antigen Receptor for Adoptive T-Cell Therapy Against B-Cell Malignancies
Yvonne Chen, Eugenia Zah, Michael Jensen, Anne Silva

09:06 AM

(467c) Targeting Cystathionine-Gamma-Lyase to the Tumor Vasculature in Enzyme Prodrug Therapy of Breast Cancer in an Immune-Competent Mouse Model
John Krais, Carla Kurkjian, Roger Harrison

09:24 AM

(467d) Advancing Next-Generation Sequencing Based Methods for Antibody Discovery and Engineering
Sai T. Reddy

09:48 AM

(467e) A Conformation-Switching Protein Probe for Detection of Alpha Synuclein Oligomers
Jin Ryoun Kim, Michael Hernandez, Yang Hu

10:06 AM

(467f) Evolving a 45-Amino Acid Ligand Scaffold for Enhanced Stability and Tumor Targeting
Benjamin J. Hackel, Max A Kruziki, Andrew Easton

10:24 AM

(467g) Imaging Agent Design for Type 1 Diabetes
Liang Zhang, Greg Thurber

10:42 AM

(467h) Engineering Exosomes As Therapeutic Delivery Vehicles
Joshua N. Leonard, Michelle E. Marcus