2014 AIChE Annual Meeting

Session: Omics in Biopharmaceutical Bioprocessing

The applications of the advanced Omics in cell engineering, clone evaluation, feeding strategy development, medium and feed development, bioreactor process parameter optimization, and quality control in manufacturing will be highlighted. The advanced Omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other Omics analysis,will be considered in this session.

Chair

Margaret Liu, The University of Alabama

Co-Chair

Jianxin Sun, The Ohio State University

Presentations

08:30 AM

(458a) Transcriptome of CHO Cells Producers of Recombinant Tpa Cultured Under Moderate Hypothermia
Andrea Bedoya-López, Mauricio Trujillo-Roldán, Norma Valdez-Cruz, Alejandro Sanchez-Flores, Karel Estrada, Octavio T. Ramírez, Claudia Altamirano

08:50 AM

(458b) A System Identification Based Approach for Phenotype Phase Plane Analysis
Andrew Damiani, Q. Peter He, Jin Wang

09:10 AM

(458c) Characterization of Protein Expression Regulators in Different CHO Hosts By Global Proteomics Analysis
Ningning Xu, Margaret Liu

09:30 AM

(458d) Strategic Genome Design to Improve Bioseparation
Bob Beitle, Ellen M. Brune, McKinzie Fruchtl, Ralph Henry, Mohammad M. Ataai

09:50 AM

(458e) Transcriptomic Analysis of Clonal Variation in Pichia Pastoris
Rochelle Aw, Geraint Barton, David J. Leak, Karen M. Polizzi

10:10 AM

(458f) Addressing the Need for a Model Selection Framework in Systems Biology Using Information Theory
Frank T. DeVilbiss, Maxim Raginsky, Doraiswami Ramkrishna

10:30 AM

(458g) Serum-Free Medium Adaptation of Chinese Hamster Ovary (CHO) Cell Lines: A Transcriptome Analysis Using RNA-Seq
Yogender Kumar Gowtham, Sarah W. Harcum, Christopher A Saski

10:50 AM

(458h) An Optimization-Based Feature Selection Methodology for the Discovery of Biomarkers from High-Dimensional Data in Clinical Applications
Yannis A. Guzman, Devaraj Jayachandran, Doraiswami Ramkrishna, Christodoulos A. Floudas