2014 AIChE Annual Meeting

Session: Interfacial Phenomena in Pharmaceuticals

This session will address the role of interfacial phenomena in drug development and processing. Topics may include, but are not limited to: physicochemical interactions between drug products and interfaces / surfaces, mass transport to / from an interface, surfactant effects, shear effects on stability, and crystallization of drug product.

Chair

Prajnaparamita Dhar, University of Kansas

Co-Chair

Mark J. Kastantin, University of Colorado

Presentations

08:30 AM

Welcoming Remarks

08:35 AM

(753a) Liquid Chromatography at the Single-Molecule Level
Joshua N. Mabry, Michael J. Skaug, Daniel K. Schwartz

08:55 AM

(753b) Water-Soluble Drug Partitioning and Adsorption in Polyelectrolyte Hydrogels
Thomas J. Dursch, Nicole O. Taylor, David E. Liu, John M. Prausnitz, Clayton J. Radke

09:15 AM

(753c) Transport of Drugs Across Surfactant Covered Emulsion Interfaces
Anuj Chauhan, Robert A. Damitz

09:35 AM

(753d) Protein Aggregation Dynamics at the Silicone Oil/Water Interface of Model Proteins Using Single-Molecule TIRF Microscopy and Dynamic Interfacial Tensiometry
Aaron C. McUmber, Theodore W. Randolph, Daniel K. Schwartz

09:55 AM

(753e) Monitoring Adsorption and Aggregation of an Intrinsically Disordered Protein at Solid Substrates
Nicolas Mucci, T. Christopher Gamblin, Prajnaparamita Dhar

10:15 AM

(753f) Stability of Monoclonal Antibody Solutions Subject to Expansion/Compression Cycles at the Air/Water Interface
Gerald Fuller, Jai A. Pathak, Gigi Lin

10:35 AM

(753g) Interactions of Bare and Protein-Loaded Adjuvants with Model Lipid Raft Mixtures at Model Interfaces
Prajnaparamita Dhar, Cory Berkland, Lorena Antunez

10:55 AM

Concluding Remarks