2013 AIChE Annual Meeting

Session: Protein Engineering III: Therapeutics I

This session will focus on protein engineering for therapeutic applications, with an emphasis on emerging topics and recent successes. Potential areas of interest include, but are not limited to, (1) advances in protein-based therapeutics, (2) proteins for cell targeting and imaging, and (3) proteins involved in disease pathology.

Chair

Laura Segatori, Rice University

Co-Chair

Yvonne Y. Chen, University of California - Los Angeles

Presentations

03:33 PM

(205b) Production of the Trimeric Influenza Hemagglutinin Stem Domain for Potentially Broadly Protective Influenza Vaccines
Yuan Lu, James R. Swartz

03:51 PM

(205c) Logical Computation By Chimeric Antigen Receptors Increases Tumor-Targeting Capability of Engineered T Cells
Yvonne Chen

04:09 PM

(205d) Engineered Mono-Specific Proteins As In Vivo Imaging Agents That Target Tumor Vasculature
Jennifer R. Cochran, Adam P. Silverman, Shiven Kapur, Gerald M. Cherf, Anne Ye

04:27 PM

(205e) Advances in Engineering a Human Cystathionine-?-Lyase for Systemic L?Methionine Depletion Cancer Therapy
Olga M. Paley, Wei-Cheng Lu, Everett M. Stone, George Georgiou, Nai-Kong Cheung, Jian Hu

04:45 PM

(205f) A Suite of Anti-Fibroblast Activation Protein-Alpha Antibodies for Targeting the Tumor Microenvironment
James A. Van Deventer, Sachdev Sidhu, Saravanan Rajan, K. Dane Wittrup

05:03 PM

(205g) Engineering Ligand Biophysics to Enhance Tumor Targeting
Benjamin J. Hackel, Brett Case

05:21 PM

(205h) Selective Inhibition of Weak-Affinity Epitope-IgE Interactions Via Heterobivalent Inhibitor Design Prevents Mast Cell Degranulation
Michael W. Handlogten, Tanyel Kiziltepe, Ana Serezani, Mark Kaplan, Basar Bilgicer