(67a) Modeling of Solid Deformation During Roller Compaction Using Air Pocket Deformation

Solid deformation during roller compaction has been the topic of major research interest over the years [1]. In addition to solid particle deformation, the air trapped between the solid particles is compressed, leading to internal voids or fractures when the roller compaction pressure is released [2]. This issue is frequently resolved in industry using vacuum pumps or special solid feeding techniques to remove the air. This work looks at the deformation of the air pockets inside the powder during roller compaction making possible a better understanding of the ribbon structure. This understanding can be used to develop better products and processes.  

[1] Cunningham, J.C., Winstead, D., Zavaliangos, A. (2010) Understanding variation in roller compaction through finite element-based process modeling Computers and Chemical Engineering 34 1058-1071

[2] Teng, Y., Qiu, Z., Wen, H. (2009) Systematical approach of formulation and process development using roller compaction European Journal of Pharmaceutics and Biopharmaceutics 73 219–229