2010 Annual Meeting

Session: Protein Engineering II - Techniques

The focus of this session is to reflect the latest advances in protein engineering and design. Suggested topics include, but are not limited to: (1) Development of high throughput screen/selection for protein engineering; (2)Development of novel protein engineering methods; (3) protein engineering via directed evolution; (4) computational protein engineering and design.

Chair

Kwon, I., University of Virginia

Co-Chair

Tullman-Ercek, D., University of California, Berkeley

Presentations

12:30 PM

(119a) An in Vitro Platform to Evolve Proteins Directly for Improved Biological Function
Lui, B. H., Cochran, J. R., Swartz, J. R.

12:50 PM

(119b) Epitope Expansion Evolution for the Affinity Maturation of Ligand-Receptor Interactions
Jones, D. S., Cochran, J. R., Kariolis, M. S.

01:10 PM

(119c) Engineering High-Affinity Antibodies Using Inner Membrane Display of Translocation Intermediates
Karlsson, A. J., Lim, H., Rocco, M. A., DeLisa, M. P.

01:30 PM

(119d) The Deg-On System: Generation of a Cell-Based High Throughput Assay for the Screening of Proteasome Activators
Segatori, L., Zhao, W.

02:00 PM

(119e) Efficient Screening of Natural Fungal Cellobiohydrolase Genes for Desirable Mutations by SCHEMA Structure-Guided Recombination
Heinzelman, P., Komor, R., Romero, P., Mohler, S., Kanaan, A., Yu, X., Arnold, F. H., Snow, C. D.

02:20 PM

(119f) De Novo Protein Design of a Conformational Switch Between α-Helical Protein and Mixed α/β Protein
Smadbeck, J., Bellows, M. L., Liu, Y., Floudas, C. A.

02:40 PM

(119g) Computational Analysis of the Protein Sequence Space: A New Method to Identify Beneficial Mutations
Bansal, P., Hall, M., Realff, M., Lee, J. H., Bommarius, A. S.