2010 Annual Meeting

Session: Protein Engineering II - Techniques

The focus of this session is to reflect the latest advances in protein engineering and design. Suggested topics include, but are not limited to: (1) Development of high throughput screen/selection for protein engineering; (2)Development of novel protein engineering methods; (3) protein engineering via directed evolution; (4) computational protein engineering and design.

Chair

Inchan Kwon, University of Virginia

Co-Chair

Danielle Tullman-Ercek, University of California, Berkeley

Presentations

12:30 PM

(119a) An in Vitro Platform to Evolve Proteins Directly for Improved Biological Function
Bertrand H. Lui, Jennifer R. Cochran, James R. Swartz

12:50 PM

(119b) Epitope Expansion Evolution for the Affinity Maturation of Ligand-Receptor Interactions
Douglas S. Jones, Jennifer R. Cochran, Mihalis S. Kariolis

01:10 PM

(119c) Engineering High-Affinity Antibodies Using Inner Membrane Display of Translocation Intermediates
Amy J. Karlsson, Hyung-Kwon Lim, Mark A. Rocco, Matthew P. DeLisa

01:30 PM

(119d) The Deg-On System: Generation of a Cell-Based High Throughput Assay for the Screening of Proteasome Activators
Laura Segatori, Wenting Zhao

02:00 PM

(119e) Efficient Screening of Natural Fungal Cellobiohydrolase Genes for Desirable Mutations by SCHEMA Structure-Guided Recombination
Pete Heinzelman, Russell Komor, Philip Romero, Shannon Mohler, Arvind Kanaan, Xinlin Yu, Frances H. Arnold, Christopher D. Snow

02:20 PM

(119f) De Novo Protein Design of a Conformational Switch Between α-Helical Protein and Mixed α/β Protein
James Smadbeck, Meghan L. Bellows, Yuhong Liu, Christodoulos A. Floudas

02:40 PM

(119g) Computational Analysis of the Protein Sequence Space: A New Method to Identify Beneficial Mutations
Prabuddha Bansal, Mélanie Hall, Matthew Realff, Jay H. Lee, Andreas S. Bommarius