2010 Annual Meeting

(681e) Temperature-Responsive and Biodegradable Highly Branched Star Dendrimer for Controlled Release of Therapeutics Across Ocular Barriers

Authors

Xiaoxun Li - Presenter, Thomas Jefferson University
Eun Seok Gil - Presenter, Pennsylvania State University
Tao Lu Lowe - Presenter, Thomas Jefferson University


A highly branched start-like dendrimer with thermo-responsive and biodegradable properties is designed and synthesized by novel systhesis methods. The chemical, physical and biological properties of the dendrimer is characterized for its application to enhance drug permeability and therapeutic effects across ocular barriers and the blood brain barrier.