(571f) Lab Scale Modular Automated Drop On Demand System: Design Principle and

One of the most promising and forward thinking technologies that can be employed in the design of controlled delivery and precise dosage formulation for small-scale manufacturing systems is drop on demand (DoD) technology for active pharmaceutical ingredient (API) deposition/printing and rapid prototyping. Applied to precision dosage formulations, DoD systems can be used to drop precise dosages of formulated drug compounds onto edible, e.g. biopolymeric, substrates creating functional and convenient drug delivery systems (DDS).

The overall goal of an integrated drop on demand (DoD) system is the ability to predict and control deposition of pharmaceutical substances onto biopolymeric substrates. In addition , the drop on demand technology will be utilized to engineer two and three-dimensional dosage structures as drug deliver systems. Precise, repeatable, and accurate dosing is needed to ensure that the dosage structures and overall drug delivery systems are efficient. To achieve the desired goals the design strategy of any DoD system must account for the varied process parameters that can affect droplet evaporation, drying, spreading, and droplet splat formation