(480e) Anti-Cancer Nanoparticle Synthesis and Characterization

Budesonide, (-)-epigallocatechin-3-gallate (EGCG) from Green tea, Irresa and resveratrol have been shown to exhibit cancer-preventive activities in preclinical studies. However, traditional atomization method was shown to be inefficient and hardly controllable in delivering size-selected drug to targeted organ by aerosol administration. In this study, we characterize two improved methods for the drug synthesis. One of the improved aerosol delivery system is composed with a custom-built atomizer coupled with an efficient solvent remove system. The other one is a compact electrospray coupled with a corona discharger.