2010 Annual Meeting

(480c) Formation and Drug Release From Particles Produced Via Flash Nanoprecipitation

Authors

Christopher W. Macosko - Presenter, University of Minnesota
Zhengxi Zhu - Presenter, University of Minnesota
Han Jing - Presenter, University of Minnesota
Adam Wohl - Presenter, University of Minnesota
Thomas Hoye - Presenter, University of Minnesota


Nanoparticles of highly insoluble drugs can be created by flash nanoprecipitation, FNP. Turbulent mixing combined with a polymer stabilizer can produce particles in the 100 nm size range, ideal for passive targeting of tumors and advantageous to increase solubility. We hypothesize that particles form by nucleation of ~10 nm which then aggregate rather than by nucleation and growth. We will report how particle structure controls drug release.