2010 Annual Meeting

(414d) Charge Reversal Liposomes for Cancer Nuclear Drug Delivery

Authors

Xinpeng Ma - Presenter, University of Wyoming
Zhuxian Zhou - Presenter, University of Wyoming
Bo Zhang - Presenter, University of Wyoming
Jianbin Tang - Presenter, Zhejiang University
Maohong Fan - Presenter, University of Wyoming
Huadong Tang - Presenter, Department of Chemical and Petroleum Engineering, University of Wyoming
Youqing Shen - Presenter, Zhejiang University
Maciej Radosz - Presenter, Department of Chemical and Petroleum Engineering, University of Wyoming
Edward Van Kirk - Presenter, University of Wyoming
William Murdoch - Presenter, University of Wyoming


Cationic liposomes have fast cellular uptakes but nonspecific cellular uptakes and are toxic, immediately clear out from the blood, accumulate in lung, Herein, we report liposomes that can undergo negative-to-positive charge-reversal triggered by the solid tumor extracellular- or lysosomal (4-5) acidity for nuclear drug delivery. Doxorubicin loaded in the liposomes is more cytotoxic to tumor cells than the free drug. The liposomes have a long blood circulation time and thus are good for in vivo cancer drug delivery.