2008 Annual Meeting

Session: Applications of Chemometrics for Process Development

Innovations in Process Development are empowered by using Chemometrics techniques to derive useful information from complex data systems. A wide range of chemometrics applications is encompassed in this session, including increased process understanding through optimization of experimental parameters, design of experiments, calibration, signal processing and enhancement of PAT development.

Chair

James Marek, Abbott Laboratories

Co-Chair

Jean Tom, Bristol Myers Squibb

Presentations

03:15 PM

Welcoming Remarks

03:20 PM

(521a) Introduction to Chemometrics -- Design of Experiments and Principal Component Analysis
Dongsheng Bu, Andrew Chu

03:45 PM

(521b) Data Exploration Analysis In Process Development: Application to API Characterization
Jose E. Tabora, Jessica Defreese, Prashant Deshpande, Jean Tom

04:10 PM

(521c) Scale-up a Complex Pharmaceutical Batch Process Using Mid-IR: The Role of Simple Peak Height Profiling, Partial Least Squares (PLS) Modeling and Dynamic Principal Component Analysis (PCA)
Shan Lin, James Marek, Samrat Mukherjee

04:35 PM

(521d) Application of Chemometrics in Process Monitoring of Synthesizing Preferred Isomer
Dongsheng Bu, Andrew Chu

05:00 PM

(521e) Utilization of Single Crystal X-Ray Studies of Process Relevant Pharmaceutical Crystal Forms to Support Qbd
John D. DiMarco, Michael A. Galella, Raymond P. Scaringe, Carolyn J. Pommier, Jack Z. Gougoutas