2008 Annual Meeting

(144b) The Design and Scale-up of An API Crystallization: Process Understanding Supported by Modeling to Achieve Consistency

Authors

James Wertman - Presenter, GlaxoSmithKline
Sonja Sharpe, GlaxoSmithKline
Christopher Werner, GlaxoSmithKline
An API crystallization was designed on bench scale with a knowledge of process thermodynamics, and scaled-up and interpreted using both empirical and semi-empirical models. This scale-up approach resulted in both process consistency and predicability.