(477e) Functionalized Liposomes for Targeting Colorectal Cancer

The goal of our studies is to develop selective drug delivery systems by incorporating in nanoparticles such as stealth liposomes (liposomes covered with polyethylene glycol) biomimetic peptide-amphiphiles (bullets) that recognize and bind in a specific manner to targets of choice. An example will be discussed of a design that targets colorectal cancer cells by specifically targeting the α₅β₁ integrin receptor. We have recently designed a novel biomimetic peptide-amphiphile that gives specific and strong adhesion with the integrin. Preliminary data will demonstrate that α₅β₁-targeted drug delivery systems can efficiently bind and internalize to colorectal cancer cells that overexpress the integrin receptor.